[The possibility of obtaining bone autograft from the anterior palate to restore limited bone defects]. / Vozmozhnost' polucheniya kostnogo autotransplantata s nebnoi poverkhnosti al'veolyarnogo otrostka verkhnei chelyusti dlya ustraneniya ogranichennykh kostnykh defektov.

OBJECTIVE: Determination of the optimal zone of the alveolar process of the upper jaw for bone autograft sampling according to cone-beam computed tomography. MATERIAL AND METHODS: A study was conducted to assess the possibility of taking a bone autograft from the palatine surface of the alveolar process of the upper jaw. The criteria for inclusion of patients in the study were the presence of a complete dentition and the absence of removed teeth in the upper jaw. A total of 50 patients participated in the study. Determination of the optimal zone for bone autograft sampling was carried out using cone-beam computed tomography (CBCT) of the upper jaw. RESULTS: The optimal area for bone autograft sampling is the area of the palatine surface of the alveolar process in the projection of the frontal group of teeth and the area of the upper jaw mound. When taking bone autograft in he projection of the frontal group of teeth and the area of the upper jaw mound with a probability of 95.11%, a 4 mm long trepan can be used. In 39.6% of cases, the parameters of the alveolar process allow the use of standard trepans with a diameter of 3.5 mm, which makes it possible to obtain a bone cylinder with a diameter of 3 mm. At the same time, in the area of the alveolar process of the frontal group of teeth, it is possible to pick up bone autograft more by 16-23 mm3 than in the the area of the upper jaw mound. CONCLUSION: The palatine surface of the alveolar process can be used for bone autograft sampling when planning to eliminate limited defects of the upper jaw. The CBCT method makes it possible to determine the optimal bone autograft sampling zone and the available bone volume, which minimizes injury to the patient.

[Comparative analysis of the effectiveness of SF-MPQ-2 and VAS for assessing the severity of pain syndrome in dental patients in the postoperative period]. / Sravnitel'nyi analiz effektivnosti oprosnika SF-MPQ-2 i vizual'noi analogovoi shkaly dlya otsenki vyrazhennosti bolevogo sindroma u stomatologicheskikh patsientov v posleoperatsionnom periode.

OBJECTIVE: Conducting a comparative analysis of the effectiveness of the Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2) and the Visual Analogue Scale (VAS) for assessing the severity of pain syndrome in dental patients in the postoperative period in dynamics. MATERIAL AND METHODS: The study included 51 patients who received dental surgical treatment. Two groups of patients were formed, depending on the type of surgery and the degree of trauma of the operation. Group 1 - low degree of injury - 28 patients; group 2 - high degree of injury - 23 patients. Patients independently filled out questionnaires at four stages of the study: before surgery, on the 1st, 3rd, and 5th days after surgery as part of scheduled visits. RESULTS AND DISCUSSION: In patients of group 2, the severity of pain symptoms was higher than in patients of group 1 in terms of pain symptoms on SF-MPQ-2 at all stages of the study, except the day before surgery. At the same time, there were no differences with the indicators of the VAS scale at any of the stages of the study. The most informative indicators of SF-MPQ-2 are the total indicator MPQ-Sum and the constant pain indicator MPQ-Const, which were significantly higher in group 2 on the 1st day after surgery, taking into account the correction for gender and age. The highest level of coincidence of indicators on VAS and the total score on MPQ-Sum was revealed on the 5th day of the operation, regardless of the degree of trauma of the operation. CONCLUSION: The use of SF-MPQ-2 with a detailed description of pain sensations is the most acceptable way to assess the degree of pain syndrome in operative surgery, especially during the period when the severity of pain symptoms is maximum (in the first days of the postoperative period).

[Comparative characteristics of the incidence of facial boils in military personnel and civilians]. / Sravnitel'naya kharakteristika zabolevaemosti furunkulom chelyustno-litsevoi oblasti u voennosluzhashchikh i grazhdanskikh lits.

THE AIM OF THE STUDY: To study the frequency and structure of the incidence of facial furuncle in military personnel of St. Petersburg and Leningrad region and civilians. To conduct a comparative analysis of the nature of the course, duration and outcome of the disease in military personnel and civilians (according to case histories). MATERIAL AND METHODS: From 5744 case histories of patients with purulent-inflammatory processes of the maxillofacial region treated at the clinic of the Department of ChLH and Surgical Dentistry of the Kirov Medical University and St. Petersburg State Medical Institution «City Hospital No. 15¼ from 2017 to 2019, 201 case histories of patients with facial furuncle were isolated and analyzed. RESULTS: According to the results of a study conducted from 2017 to 2019 in the clinic of the Department of CHLH and surgical Dentistry, a facial furuncle was detected in 65 cases. In the general structure of purulent-inflammatory diseases of the maxillofacial region, it was 3.1%. In the department of ChLH GB No. 15, 136 people were treated, which amounted to 3.7%. A lower percentage of the disease in military personnel is associated with early detection and timely initiation of treatment of purulent-inflammatory diseases of the skin. Weekly inspections of military personnel in military units, allow to avoid the development of complicated forms of their course. 95.0% of military personnel (47.0% of them contractors) and 51.0% of civilians were in the age group from 17 to 21 years. The main cause of the disease - hypothermia - in military personnel was 32.1%, in civilians - 20.9%. More often, the furuncle disease occurred in the spring: in military personnel in 44.6%, in civilians in 30.7% of cases. Localization of a boil in the buccal region occurred in military personnel in 15.4% of cases, and in civilians - in 20.8% of cases. CONCLUSION: To prevent the disease of facial frunculus in military personnel, it is necessary to improve methods of prevention, diagnosis and treatment of patients, to provide consultations of related specialists: dermatovenerologist, endocrinologist, immunologist. In addition, it is necessary to observe the rules of personal hygiene with the use of individual skin care products (according to the type of facial skin), hardening of the body and vitamin therapy.

[Long-term results of dental implantation in military personnel]. / Otdalennye rezul'taty dental'noi implantatsii u voennosluzhashchikh.

BACKGROUND: Currently, the use of the dental implantation method for the medical service of the Armed Forces of the Russian Federation is quite new. The method of dental implantation makes it possible to eliminate defects in the dentition of military personnel and other contingents eligible for medical care in military medical institutions of the Ministry of Defense of Russia. OBJECTIVE: The aim of the study is to substantiate the medical effectiveness of the use of dental implantation in military healthcare. MATERIAL AND METHODS: The study was conducted on the basis of the Department of Maxillofacial Surgery and Surgical Dentistry of the Military Medical Academy named after S.M. Kirov. The study is based on the analysis of long-term results of dental implantation according to medical histories and outpatient records. The study was conducted in 3 stages: stage 1 - study of the medical histories of patients who underwent dental implantation; stage 2 - examination of patients with dental implants and analysis of long-term results; stage 3 - a patient questionnaire was conducted to determine the effectiveness of dental implantation. RESULTS: The structure of complications during dental implantation was revealed. Clinical examples of long-term results of prosthetics using dental implants are presented. It has been established that due to the peculiarity of military service and the remoteness of the locations of military units from the military medical organization, it is not always possible to conduct regular medical examinations and examinations of patients. To identify early symptoms of peri-implantitis, which is more often asymptomatic, preventive examinations of military personnel should be carried out 1-2 times a year. CONCLUSION: To increase the service life of an orthopedic structure with installed dental implants, regular preventive examinations of patients to identify pathological processes are important. In favor of implantation, there is a choice for some categories of military personnel. This is especially important for flight and naval personnel, since dentures installed on dental implants are the only way to preserve their professional suitability in the military accounting specialty. The presence of teeth and the absence of removable dentures is an important requirement when performing combat missions.

[A pseudoallergic reaction involved in developing bullous oral lichen planus in patients with increased gastric acid-producing function]. / Rol' psevdoallergicheskoi reaktsii v razvitii bulleznoi formy krasnogo ploskogo lishaya slizistoi obolochki rta u bol'nykh s povyshennoi kislotoobrazuyushchei funktsiei zheludka.

Lichen planus of the oral mucosa (LPOOR) is a chronic autoimmune disease. With a complicated course of the disease, other clinical and pathomorphological signs are added to the clinical picture of the reticular form, including blisters in the bullous form of the disease. It is known that LPOOR develops mainly by the mechanism of delayed-type hypersensitivity reaction, and in complicated forms - with the addition of a true allergic reaction of immediate-type hypersensitivity. OBJECTIVE: To determine the role of pseudo-allergic reaction in the development of the bullous form of LPR in patients with increased acid-forming function of the stomach. MATERIAL AND METHODS: The level of histamine in blood was studied by high-performance liquid chromatography and blood IgE by the immunochemiluminescent method in 38 patients with the bullous form of LPOOR against the background of acid-dependent diseases and 14 patients with the reticular form of LP RR with the absence of hyperchlorhydria. For the treatment of patients with the bullous form of LPOOR, drugs were used - H1 and H2 receptor blockers and proton pump inhibitors. RESULTS: A positive result was obtained in 68.4% of cases. CONCLUSION: Thus, a pseudoallergic component has been established in the development of the bullous form of the LP of ROS against the background of increased acid-forming function of the stomach.

Morphological and Molecular-Biological Features of Inflammatory and Regeneratory Processes in Peridont Tissues with Periimplantitis and Periodontitis.

A morphological and immunohistochemical study of periodontal tissues was performed in patients with chronic generalized periodontitis who underwent dental implantation. We studied 44 biopsy specimens from 21 patients (13 women and 8 men) aged 35-60 years with a diagnosis of periimplantation mucositis (7 patients), periimplantitis (8 patients), and severe chronic generalized periodontitis (6 patients). It was established that periimplantitis differs from periimplantation mucositis by a more pronounced inflammatory reaction with a clear predominance of plasma cells in the infiltrate, which captures the fibrous capsule around the implant, destroys it and further spreads to the bone tissue. Based on the immunohistochemical differences in SMA, VEGF, and Ki-67, it is concluded that periimplantation mucositis and periimplantitis are successive stages of progression of the same process. When comparing chronic generalized periodontitis and periimplantitis, the latter shows much more pronounced inflammatory and destructive processes in the area of the implant, due to the addition of immune inflammation, impaired regeneration processes, and destruction of bone tissue.

Immunohistochemical and Morphological Study of Periodontal Tissues in Predicting the Results of Dental Implantation in Patients with Chronic Periodontitis.

Morphological and immunohistochemical examination was made on 24 gum biopsies obtained from 35- to 60-year-old patients with diagnosis of partial secondary adentia, chronic generalized moderate to severe periodontitis (19 patients), as well as on the biopsy samples from five patients without pathological periodontal changes who underwent dental implantation. Serial paraffin sections were treated with antibodies against Ki-67, VEGF, and SMA. In patients with severe chronic periodontitis, a high proliferative activity of epithelium indicative of hyperplastic changes was observed, as well as a reduced number of the SMA-positive cells and actual absence of the SMA-positive cell couplings associated with the "growth zones" in tissues, which testifies indirectly to a lower tissue regenerative capacity. Hence, before dental implantation, additional anti-inflammatory and pro-regenerative treatment is required.

[Improvement of training quality in continuous medial education of dentists and maxillofacial surgeons]. / Povyshenie kachestva podgotovki spetsialistov-stomatologov i cheliustno-litsevykh khirurgov v sisteme nepreryvnogo meditsinskogo obrazovaniia.

The new concept of continuous medical education is based on individual learning paths of each specialist in conjunction with the use of modern educational technologies, including IT. The aim of this study was to undertake a review of modern methods of health care professionals training in the framework of continuous medical education profile introduced by the Ministry of Health. The paper presents the best IT practices of Central Research Institute of Dentistry and Maxillofacial Surgery in the training of dentists and maxillofacial surgeons aimed for the modernization of medical education.

[Formation of bone in critical calvarias defects in rats under the influence of bisphosphonate alendronate Na complex]. / Novoobrazovanie kostnoi tkani v kriticheskikh defektakh svoda cherepa krys pod vliyaniem kompleksa, soderzhashchego bisfosfonat alendronat natriya.

The aim of the study was to investigate dynamic of tissue structures in critical defects of calvaria of rats after inoculation of bisphosphonate (BF) alendronate Na complex into bone defects. Animal model included 24 Wistar rats divided in 3 groups: spontaneous healing under blot clot (1), inoculation of carbonate hydroxide apatite ß-tricalcium phosphate blocks (2) and BF alendronate Na complex (3) on 15, 30, 60 and 90 experiment day. New bone formation was observed in group 3 as opposed to groups 1 and 2.

[Modern approaches to dental implants placement in deficient alveolar bone]. / Sovremennye podkhody k primeneniyu metoda dental'noi implantatsii pri atrofii i defektakh kostnoi tkani chelyustei.

The paper presents statistical data on implant placement procedures in Central Research Institute of Dentistry and Maxillofacial Surgery (Moscow, Russia) in 2010-2015. In 64% of cases inadequate bone volume was attributed to alveolar bone atrophy. Bone deficiency was equally often in upper and lower jaws (in 49.3 and 50.7%, correspondently) but varied in forms with complex configurations to be more specific for maxilla. The study also includes a series of clinical cases illustrating implant placement procedures in anatomically unfavorable settings.

[Promoting pharmacovigilance monitoring in health care organization].

The article considers the practical aspects of the organization of the pharmacovigilance of medicines at the level of healthcare institutions.